منابع مشابه
Paradoxical insights into whole body metabolic adaptations following SGLT2 inhibition.
It is well known that glycemic control over time reduces microvascular and macrovascular complications in human subjects with type 2 diabetes. In addition, preclinical models of type 2 diabetes have demonstrated that long-term hyperglycemia exacerbates insulin resistance and reduces β cell function; therefore, therapies that reduce blood glucose levels are of great interest in not only controll...
متن کاملMechanism of Action of Sglt2-inhibitors
T2DM individuals manifest a 2-3 times greater risk of CV events compared to non-diabetics, and CV mortality is responsible for ~70% of total mortality. In T2DM patients without MI, risk of CV death is similar to individuals without diabetes with prior MI.1 Although hyperglycemia is a strong risk factor for microvascular complications, it is a weak risk factor for CV disease (CVD), and intervent...
متن کاملSGLT2 Inhibitors and the Diabetic Kidney.
Diabetic nephropathy (DN) is the most common cause of end-stage renal disease worldwide. Blood glucose and blood pressure control reduce the risk of developing this complication; however, once DN is established, it is only possible to slow progression. Sodium-glucose cotransporter 2 (SGLT2) inhibitors, the most recent glucose-lowering oral agents, may have the potential to exert nephroprotectio...
متن کاملFurther Insights into " the Stability of Supply Chains "
Riddalls and Bennett (2002) presented a stability criterion for a supply chain model in continuous time. In this short technical note we show this solution is in error and provide the correct stability criterion. The results are substantiated by deriving the correct criterion from with several independent theoretical analyses and validating the solution via numerical simulation. The weight of e...
متن کاملFurther Insights into Brevetoxin Metabolism by de Novo Radiolabeling
The toxic dinoflagellate Karenia brevis, responsible for early harmful algal blooms in the Gulf of Mexico, produces many secondary metabolites, including potent neurotoxins called brevetoxins (PbTx). These compounds have been identified as toxic agents for humans, and they are also responsible for the deaths of several marine organisms. The overall biosynthesis of these highly complex metabolit...
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ژورنال
عنوان ژورنال: Nature Reviews Cardiology
سال: 2017
ISSN: 1759-5002,1759-5010
DOI: 10.1038/nrcardio.2017.198